PNPT1 and C2orf74

Data Source:
BioGRID (affinity chromatography technology)

		PNPT1	C2orf74
Description		polyribonucleotide nucleotidyltransferase 1	chromosome 2 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Polysomal Ribosome Mitochondrial Degradosome	Integral Component Of Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Poly(G) Binding MiRNA Binding	Protein Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration RNA Polyadenylation Negative Regulation Of Growth Protein Homooligomerization Response To CAMP Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Mitochondrion Morphogenesis Nuclear Polyadenylation-dependent MRNA Catabolic Process Mitotic Cell Cycle Arrest RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Height ( 28552196 25429064 18391951) Intraocular pressure ( 29617998 31959993) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196)	Crohn's disease ( 22412388 21102463) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233)
Interacting Genes		2 interacting genes: ADARB1 HSPB1	2 interacting genes: POT1 SMAGP
Entrez ID		87178	339804
HPRD ID		18493	19550
Ensembl ID		ENSG00000138035	ENSG00000237651
Uniprot IDs		Q8TCS8	A8MZ97 C9JBF1
PDB IDs		3U1K 5ZF6
Enriched GO Terms of Interacting Partners?
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