HSD17B6 and PDE2A

Data Source:
BioGRID (affinity chromatography technology)

		HSD17B6	PDE2A
Description		hydroxysteroid 17-beta dehydrogenase 6	phosphodiesterase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Early Endosome Membrane	Nucleus Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Catalytic Activity Estradiol 17-beta-dehydrogenase Activity Retinol Dehydrogenase Activity Electron Transfer Activity Oxidoreductase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity	Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Zinc Ion Binding CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Protein Homodimerization Activity 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Androgen Biosynthetic Process Androgen Catabolic Process Electron Transport Chain Brexanolone Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CAMP-mediated Signaling CGMP-mediated Signaling Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		The canonical retinoid cycle in rods (twilight vision)	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Asthma ( 31619474) Cerebral amyloid deposition (PET imaging) ( 30361487) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet aggregation ( 20526338) Platelet count ( 27863252) Red blood cell count ( 29403010)	Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes
Entrez ID		8630	5138
HPRD ID		09431	04041
Ensembl ID		ENSG00000025423	ENSG00000186642
Uniprot IDs		A0A024RB43 O14756	O00408 Q8IW54
PDB IDs			1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?
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