AGPS and PDE11A

Data Source:
BioGRID (proximity labelling technology)

		AGPS	PDE11A
Description		alkylglycerone phosphate synthase	phosphodiesterase 11A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Cellular_component Cytosol
	Molecular Function	Protein Binding Alkylglycerone-phosphate Synthase Activity Oxidoreductase Activity FAD Binding	Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Protein Targeting To Peroxisome Lipid Biosynthetic Process Ether Lipid Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Metabolic Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling
Pathways		Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Tadalafil Trapidil
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Height ( 28552196)	Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Diastolic blood pressure ( 29212154) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Height ( 28552196 20881960) High myopia ( 31816047) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: GNPAT GORASP1
Entrez ID		8540	50940
HPRD ID		04337	05391
Ensembl ID		ENSG00000018510	ENSG00000128655
Uniprot IDs		B7Z3Q4 O00116	Q9HCR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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