RIOX2 and ARID5B

Data Source:
BioGRID (pull down)

		RIOX2	ARID5B
Description		ribosomal oxygenase 2	AT-rich interaction domain 5B
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GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding 2-oxoglutarate-dependent Dioxygenase Activity Histone Demethylase Activity (H3-K4 Specific) Identical Protein Binding Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific)	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Histone H3-K4 Demethylation Ribosome Biogenesis Negative Regulation Of Transcription, DNA-templated Histone H3-K36 Demethylation	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Nitrogen Compound Metabolic Process Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor
Pathways		HDMs demethylate histones	HDMs demethylate histones
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 28817678 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 29760442 30894546) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 32888494 27863252) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 23022100) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 27399966 23273568 26502338) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 32499647) Vitiligo ( 27723757)
Interacting Genes		4 interacting genes: APP H3C3 LNX1 MYC
Entrez ID		84864	84159
HPRD ID		17575	18880
Ensembl ID		ENSG00000170854	ENSG00000150347
Uniprot IDs		A0A6M8YDW1 Q8IUF8	Q14865
PDB IDs		2XDV 4BU2 4BXF	1IG6 2OEH
Enriched GO Terms of Interacting Partners?
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