SEMA7A and CHRNA5

Data Source:
BioGRID (affinity chromatography technology)

		SEMA7A	CHRNA5
Description		semaphorin 7A (John Milton Hagen blood group)	cholinergic receptor nicotinic alpha 5 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuron Projection Synapse Postsynaptic Membrane Dopaminergic Synapse
	Molecular Function	Integrin Binding Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Osteoblast Differentiation Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Axon Guidance Olfactory Lobe Development Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Axon Extension Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Other semaphorin interactions Other semaphorin interactions	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Nicotine Butabarbital Ethanol
Diseases
GWAS		Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)	Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 22080838 28166215 19300482 20173748) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) FagerstrÓ§m test for nicotine dependence ( 31294817) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 28604730 19836008) Lung cancer ( 18385676 28604730 18385738 18780872 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 25056061 29483656) Serum albumin level ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		1 interacting genes: PLXNC1	1 interacting genes: CHRNB4
Entrez ID		8482	1138
HPRD ID		07081	00334
Ensembl ID		ENSG00000138623	ENSG00000169684
Uniprot IDs		B3KMH6 F5GYX3 O75326	H0YM98 P30532 Q6EWN4
PDB IDs		3NVQ
Enriched GO Terms of Interacting Partners?
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