KDM2B and TCTN2

Data Source:
HPRD (in vivo)

		KDM2B	TCTN2
Description		lysine demethylase 2B	tectonic family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus PcG Protein Complex	Cytoplasm Cytoskeleton Integral Component Of Membrane MKS Complex Ciliary Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Demethylation Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Histone H2A Monoubiquitination Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Histone H3-K36 Demethylation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation	Smoothened Signaling Pathway Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Protein Localization To Ciliary Transition Zone
Pathways		HDMs demethylate histones	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: CEBPE FOS H3C1 LZTR1 UBE2D1
Entrez ID		84678	79867
HPRD ID		12362	07805
Ensembl ID		ENSG00000089094	ENSG00000168778
Uniprot IDs		B4DSN4 Q8NHM5	Q96GX1
PDB IDs		4O64 5JH5 6BVA
Enriched GO Terms of Interacting Partners?
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