BRIP1 and MRPS23

Data Source:
HPRD (in vitro)

		BRIP1	MRPS23
Description		BRCA1 interacting protein C-terminal helicase 1	mitochondrial ribosomal protein S23
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane	Mitochondrion Mitochondrial Inner Membrane Ribosome Nuclear Membrane
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination	Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases		Fanconi anemia
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Obstetric antiphospholipid syndrome ( 28424481)
Interacting Genes		10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1	5 interacting genes: GSC2 HSPB1 POLR1C PTEN USHBP1
Entrez ID		83990	51649
HPRD ID		05797	17592
Ensembl ID		ENSG00000136492	ENSG00000181610
Uniprot IDs		Q9BX63	Q9Y3D9
PDB IDs		1T15 1T29 3AL3	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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