BAP1 and PARP3

Data Source:
HPRD (in vivo)

		BAP1	PARP3
Description		BRCA1 associated protein 1	poly(ADP-ribose) polymerase family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex	Nucleoplasm Nucleolus Cytoplasm Centriole Nuclear Body Site Of Double-strand Break Intercellular Bridge
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity	Catalytic Activity NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Telomere Maintenance DNA Repair Double-strand Break Repair Protein ADP-ribosylation DNA ADP-ribosylation Negative Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Telomerase RNA Reverse Transcriptase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs			2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one -ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		27 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	4 interacting genes: APP H1-1 MEOX2 PARP1
Entrez ID		8314	10039
HPRD ID		04366	06370
Ensembl ID		ENSG00000163930	ENSG00000041880
Uniprot IDs		A0A024R305 F8W6N3 Q92560	A0A024R318 Q9Y6F1
PDB IDs			2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?
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