SEL1L2 and MACROD2

Data Source:
BioGRID (two hybrid)

		SEL1L2	MACROD2
Description		SEL1L2 adaptor subunit of ERAD E3 ligase	mono-ADP ribosylhydrolase 2
Image		No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Ubiquitin-protein Transferase Activity	Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Protein Ubiquitination Ubiquitin-dependent ERAD Pathway	Cellular Response To DNA Damage Stimulus Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Advanced glycation end-product levels ( 26915486) Alzheimer's disease in APOE e4- carriers ( 25778476) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 31379025) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Autism ( 20663923) Autism spectrum disorder ( 30804558) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain connectivity ( 23471985) Chronotype ( 30696823) Common carotid intima-media thickness in HIV infection ( 29206233) Coronary artery aneurysm in Kawasaki disease ( 27171184) Dimensional psychopathology (Negative) ( 29496196) Dimensional psychopathology (Positive) ( 29496196) Eating disorders ( 23568457) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hip circumference ( 28552196) Intelligence (MTAG) ( 29326435) Male fertility ( 22633400) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Non-alcoholic fatty liver disease histology (other) ( 20708005) Obesity-related traits ( 23251661) Percentage gas trapping ( 26030696) Presence of antiphospholipid antibodies ( 27098658 23509613) Sleep duration ( 30846698) Smoking behaviour (age at first cigarette) ( 30679032) Thyroid-associated orbitopathy in graves' disease ( 27304844) Waist circumference adjusted for body mass index ( 28552196) Weight ( 28552196) White matter lesion progression ( 26451028)
Interacting Genes
Entrez ID		80343	140733
HPRD ID		19376	16640
Ensembl ID		ENSG00000101251	ENSG00000172264
Uniprot IDs		Q5TEA6	A1Z1Q3
PDB IDs			4IQY 6Y4Y 6Y4Z 6Y73
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?