FHOD3 and DSC2

Data Source:
HPRD (in vitro)

		FHOD3	DSC2
Description		formin homology 2 domain containing 3	desmocollin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Striated Muscle Thin Filament Z Disc	Cornified Envelope Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Negative Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Sarcomere Organization Actin Filament Network Formation Cardiac Myofibril Assembly	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Keratinization Cornification Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Adverse response to drug ( 30420678) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Height ( 31562340) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 27841878 30578418) QRS duration ( 27659466) Response to antipsychotic treatment ( 20195266) Resting heart rate ( 29769521 27798624) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483)
Interacting Genes			6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3
Entrez ID		80206	1824
HPRD ID		16894	00512
Ensembl ID		ENSG00000134775	ENSG00000134755
Uniprot IDs		Q2V2M9	A0A3B3ISU0 Q02487
PDB IDs			5ERP 5J5J
Enriched GO Terms of Interacting Partners?
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