FRAS1 and ANTXR2

Data Source:
BioGRID (affinity chromatography technology)

		FRAS1	ANTXR2
Description		Fraser extracellular matrix complex subunit 1	ANTXR cell adhesion molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Protein Transport Embryonic Limb Morphogenesis Skin Development Roof Of Mouth Development	Toxin Transport
Pathways
Drugs			MDX-1303
Diseases		Fraser syndrome	Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Blond vs. brown/black hair color ( 30531825) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes			8 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 LAMB1 LAMC1 LRP6 SMAD2
Entrez ID		80144	118429
HPRD ID		06382	07452
Ensembl ID		ENSG00000138759	ENSG00000163297
Uniprot IDs		Q86XX4	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs			1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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