TCTN2 and KDM2B

Data Source:
HPRD (in vivo)

		TCTN2	KDM2B
Description		tectonic family member 2	lysine demethylase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Integral Component Of Membrane MKS Complex Ciliary Membrane	Nucleus Nucleoplasm Nucleolus PcG Protein Complex
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Smoothened Signaling Pathway Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Protein Localization To Ciliary Transition Zone	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Demethylation Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Histone H2A Monoubiquitination Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Histone H3-K36 Demethylation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Anchoring of the basal body to the plasma membrane	HDMs demethylate histones
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)
Interacting Genes			5 interacting genes: CEBPE FOS H3C1 LZTR1 UBE2D1
Entrez ID		79867	84678
HPRD ID		07805	12362
Ensembl ID		ENSG00000168778	ENSG00000089094
Uniprot IDs		Q96GX1	B4DSN4 Q8NHM5
PDB IDs			4O64 5JH5 6BVA
Enriched GO Terms of Interacting Partners?
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