PDZD3 and NLRX1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PDZD3	NLRX1
Description		PDZ domain containing 3	NLR family member X1
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GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Protein Binding ATP Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	Viral Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways		Intestinal infectious diseases	DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	1 interacting genes: SARM1
Entrez ID		79849	79671
HPRD ID		06191	17640
Ensembl ID		ENSG00000172367	ENSG00000160703
Uniprot IDs		B0YJ61 Q86UT5	Q86UT6
PDB IDs		2V90	3UN9
Enriched GO Terms of Interacting Partners?
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