KCTD17 and SPHK1

Data Source:
BioGRID (affinity chromatography technology)

		KCTD17	SPHK1
Description		potassium channel tetramerization domain containing 17	sphingosine kinase 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Presynapse
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding	Magnesium Ion Binding Lipid Kinase Activity DNA Binding NAD+ Kinase Activity Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphinganine Kinase Activity Acetyltransferase Activity D-erythro-sphingosine Kinase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding
	Biological Process	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Folding Protein Acetylation Sphingolipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Brain Development Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phosphorylation Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Lipid Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion
Pathways			Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Iron status biomarkers (ferritin levels) ( 28334935) Mean corpuscular hemoglobin concentration ( 28453575) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell traits ( 23222517)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: AQP1 CRK CUL3 DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1	12 interacting genes: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6
Entrez ID		79734	8877
HPRD ID		07764	04768
Ensembl ID		ENSG00000100379	ENSG00000176170
Uniprot IDs		A0A087WX35 Q8N5Z5	Q53ZR5 Q9NYA1
PDB IDs		5A6R	3VZB 3VZC 3VZD 4L02 4V24
Enriched GO Terms of Interacting Partners?
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