NARS2 and ALG8

Data Source:
BioGRID (two hybrid)

		NARS2	ALG8
Description		asparaginyl-tRNA synthetase 2, mitochondrial	ALG8 alpha-1,3-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Nucleic Acid Binding Asparagine-tRNA Ligase Activity ATP Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Asparaginyl-tRNA Aminoacylation	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways		Mitochondrial tRNA aminoacylation	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs		Asparagine
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Alzheimer's disease (survival time) ( 25649651) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Estimated glomerular filtration rate ( 31451708) High light scatter reticulocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990) Verbal declarative memory ( 25648963)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes			12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		79731	79053
HPRD ID		08026	10480
Ensembl ID		ENSG00000137513	ENSG00000159063
Uniprot IDs		B3KPX5 Q96I59 Q9H5H1	A0A024R5K5 Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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