BRME1 and GDF15

Data Source:
BioGRID (affinity chromatography technology)

		BRME1	GDF15
Description		break repair meiotic recombinase recruitment factor 1	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Chromosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Double-strand Break Repair Involved In Meiotic Recombination	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		32 interacting genes: ADAMTSL4 AIMP2 APP C19orf25 CENPQ COPS4 CTNNAL1 CYSRT1 EWSR1 FAM9B FBXO25 GPS2 HAUS3 HOMER1 IKBKG KRT31 KRT34 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NBPF19 NOTCH2NLA PSMA6 RABL6 RUNX1T1 STXBP1 TRIM23 TSC22D3 VCL	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		79173	9518
HPRD ID		14415	05608
Ensembl ID		ENSG00000132016	ENSG00000130513
Uniprot IDs		Q0VDD7	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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