ALG8 and TMEM126B

Data Source:
BioGRID (biochemical)

		ALG8	TMEM126B
Description		ALG8 alpha-1,3-glucosyltransferase	transmembrane protein 126B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Molecular_function Protein Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)	Complex I biogenesis
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Tourette syndrome ( 30818990)	Height ( 19570815) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A	2 interacting genes: APP MRFAP1L1
Entrez ID		79053	55863
HPRD ID		10480	13715
Ensembl ID		ENSG00000159063	ENSG00000171204
Uniprot IDs		A0A024R5K5 Q9BVK2	A0A024R5L4 Q8IUX1
PDB IDs
Enriched GO Terms of Interacting Partners?
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