CAD and LTBP1

Data Source:
BioGRID (biochemical)

		CAD	LTBP1
Description		carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	latent transforming growth factor beta binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Extracellular Exosome	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix
	Molecular Function	Aspartate Carbamoyltransferase Activity Carbamoyl-phosphate Synthase (glutamine-hydrolyzing) Activity Dihydroorotase Activity Protein Kinase Activity ATP Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Aspartate Binding	Transforming Growth Factor Beta-activated Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding
	Biological Process	Liver Development 'de Novo' Pyrimidine Nucleobase Biosynthetic Process UTP Biosynthetic Process Glutamine Metabolic Process Nitrogen Compound Metabolic Process Heart Development Female Pregnancy Lactation Response To Amine Drug Metabolic Process Peptidyl-threonine Phosphorylation Citrulline Biosynthetic Process Response To Caffeine Animal Organ Regeneration Response To Insulin Response To Testosterone Cellular Response To Drug Response To Starvation 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Protein Autophosphorylation Response To Cortisol Cellular Response To Epidermal Growth Factor Stimulus	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Activation
Pathways		Pyrimidine biosynthesis	Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Sparfosic acid
Diseases
GWAS		Triglyceride levels ( 32203549)	Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 32528159 29760442) Diverticular disease ( 30177863) Height ( 28552196 20881960 25282103 25429064 19893584 23563607 31562340 20189936) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29617998 29785010 29235454) Knee osteoarthritis ( 30374069) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		11 interacting genes: CASP3 HTRA2 MAPK1 NEDD4 PPP1CA PPP2CA PRKACA PTEN RAD9A SUMO2 YWHAG	11 interacting genes: ATN1 CACNA1A FBN1 FBN2 FN1 HTRA1 IGFBP3 IGFBP5 ITGB5 TGFB1 TGM2
Entrez ID		790	4052
HPRD ID		06437	01039
Ensembl ID		ENSG00000084774	ENSG00000049323
Uniprot IDs		F8VPD4 P27708	B7ZLY3 Q14766
PDB IDs		4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q 5G1N 5G1O 5G1P 5YNZ 6HFD 6HFE 6HFF 6HFH 6HFI 6HFJ 6HFK 6HFL 6HFN 6HFP 6HFQ 6HFR 6HFS 6HFU 6HG1	1KSQ
Enriched GO Terms of Interacting Partners?
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