MANF and TWF2

Data Source:
BioGRID (affinity chromatography technology)

		MANF	TWF2
Description		mesencephalic astrocyte derived neurotrophic factor	twinfilin actin binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Lumen Perinuclear Region Of Cytoplasm	Cytoplasm Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Growth Factor Activity Sulfatide Binding	RNA Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Actin Filament Binding
	Biological Process	Platelet Degranulation Response To Unfolded Protein Signal Transduction Neuron Projection Development Dopaminergic Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Sequestering Of Actin Monomers Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Diverticular disease ( 30177863)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Schizophrenia ( 23974872)
Interacting Genes		1 interacting genes: ZDHHC17	6 interacting genes: ARHGDIA CHGB FOXJ1 ILK POT1 TERF2IP
Entrez ID		7873	11344
HPRD ID		03558	08464
Ensembl ID		ENSG00000145050	ENSG00000247596
Uniprot IDs		A8K878 P55145	Q6IBS0
PDB IDs		2KVD 2KVE 2W51	2VAC 2W0I
Enriched GO Terms of Interacting Partners?
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