ALMS1 and SLC4A5

Data Source:
BioGRID (affinity chromatography technology)

		ALMS1	SLC4A5
Description		ALMS1 centrosome and basal body associated protein	solute carrier family 4 member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol Cilium	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity Anion:anion Antiporter Activity Transmembrane Transporter Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis	Epithelial Cell Development Renal System Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Gene Expression Inorganic Anion Transport Bicarbonate Transport Cerebrospinal Fluid Secretion Sodium Ion Transmembrane Transport Mitochondrion Distribution Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Retina Development In Camera-type Eye Anion Transmembrane Transport
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Bicarbonate transporters
Drugs
Diseases		Alstrom syndrome (AS)
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Intelligence (MTAG) ( 29326435) Menarche (age at onset) ( 27182965) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites (H-NMR features) ( 24586186)	Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GTF2IRD1 LIG4 MEGF10
Entrez ID		7840	57835
HPRD ID		06023	08420
Ensembl ID		ENSG00000116127	ENSG00000188687
Uniprot IDs		Q8TCU4	Q9BY07
PDB IDs
Enriched GO Terms of Interacting Partners?
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