WFS1 and S100P

Data Source:
HPRD (in vivo)

		WFS1	S100P
Description		wolframin ER transmembrane glycoprotein	S100 calcium binding protein P
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite	Extracellular Region Nucleus Nucleoplasm Cytoplasm Microvillus Membrane Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding ATPase Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein Homodimerization Activity Cadherin Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Response To Organic Substance Neutrophil Degranulation Endothelial Cell Migration
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Neutrophil degranulation
Drugs			Cromoglicic acid
Diseases		Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)	Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1	15 interacting genes: AGER ARC CACYBP EZR S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI UBL4A
Entrez ID		7466	6286
HPRD ID		05864	02792
Ensembl ID		ENSG00000109501	ENSG00000163993
Uniprot IDs		A0A0S2Z4V6 O76024	P25815
PDB IDs			1J55 1OZO 2MJW
Enriched GO Terms of Interacting Partners?
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