TNFSF4 and SOAT1

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (in vitro, two hybrid)

		TNFSF4	SOAT1
Description		TNF superfamily member 4	sterol O-acyltransferase 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding	Fatty-acyl-CoA Binding Sterol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Cholesterol Binding Cholesterol O-acyltransferase Activity
	Biological Process	Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Cholesterol Metabolic Process Macrophage Derived Foam Cell Differentiation Cholesterol Storage Cholesterol Efflux Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Cholesterol Esterification Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		TNFs bind their physiological receptors	LDL clearance
Drugs			Ezetimibe Hesperetin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 31361310 30929738 27182965 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: TNFRSF4 TRAF2	1 interacting genes: TERF1
Entrez ID		7292	6646
HPRD ID		04668	00033
Ensembl ID		ENSG00000117586	ENSG00000057252
Uniprot IDs		A0A024R937 P23510	P35610
PDB IDs		2HEV	6L47 6L48 6P2J 6P2P 6VUM
Enriched GO Terms of Interacting Partners?
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