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TNFSF4 and CERS2
Data Source:
BioGRID
(affinity chromatography technology)
TNFSF4
CERS2
Description
TNF superfamily member 4
ceramide synthase 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Signaling Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
DNA Binding
Protein Binding
N-acyltransferase Activity
Sphingosine N-acyltransferase Activity
Biological Process
Positive Regulation Of Cytokine Production
Defense Response To Nematode
Acute Inflammatory Response
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Regulation Of Adaptive Immune Response
Positive Regulation Of Type 2 Immune Response
Positive Regulation Of Immunoglobulin Mediated Immune Response
Inflammatory Response
Immune Response
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Virus
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Memory T Cell Activation
T-helper 2 Cell Activation
Response To Nitrogen Dioxide
Positive Regulation Of T Cell Proliferation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Memory T Cell Differentiation
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Alpha-beta T Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of B Cell Activation
Cellular Response To Lipopolysaccharide
Cellular Response To Prostaglandin E Stimulus
Chemokine (C-C Motif) Ligand 11 Production
Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Sphingolipid Biosynthetic Process
Ceramide Biosynthetic Process
Negative Regulation Of Axon Regeneration
Negative Regulation Of Schwann Cell Migration
Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways
TNFs bind their physiological receptors
Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Alopecia areata (
25337690
)
Asthma (
31361310
30929738
27182965
32296059
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Celiac disease (
20190752
24999842
)
Crohn's disease (
21102463
)
Diabetic retinopathy (
21441570
)
IgA levels (
28628107
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Systemic lupus erythematosus (
27399966
23273568
26663301
26502338
28714469
19838193
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
31672989
)
Vein graft stenosis in coronary artery bypass grafting (
25881214
)
Apolipoprotein A1 levels (
32203549
)
Body mass index (
26426971
)
Estimated glomerular filtration rate (
31152163
31015462
)
Facial attractiveness (female raters) (
30946739
)
Glycated hemoglobin levels (
28898252
)
HDL cholesterol (
30275531
)
HDL cholesterol levels (
32203549
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
)
Reticulocyte fraction of red cells (
27863252
)
Rhegmatogenous retinal detachment (
23585552
)
Interacting Genes
2 interacting genes:
TNFRSF4
TRAF2
12 interacting genes:
ASGR1
ASGR2
ATP6V0C
DRD2
HSP90AA1
IER3IP1
PEX6
SLC19A2
SLC22A1
SLC39A1
TMBIM6
YIF1A
Entrez ID
7292
29956
HPRD ID
04668
06080
Ensembl ID
ENSG00000117586
ENSG00000143418
Uniprot IDs
A0A024R937
P23510
Q96G23
PDB IDs
2HEV
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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