TPM4 and RAB8A

Data Source:
BioGRID (affinity chromatography technology)

		TPM4	RAB8A
Description		tropomyosin 4	RAB8A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Extracellular Exosome	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Non-motile Cilium Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Muscle Filament Sliding	Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Mean platelet volume ( 31080455 22139419 32888494 22423221 27863252) Platelet count ( 26805783 22139419 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)	Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: JRK LNX1 NOD2 PACSIN1 PICK1 SMURF1 SNAPIN TCERG1 TPM1 TPM3 TRIP6	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		7171	4218
HPRD ID		11734	01296
Ensembl ID		ENSG00000167460	ENSG00000167461
Uniprot IDs		A0A5F9UN72 K7ENT6 P67936 V9HW56	A0A024R7I3 P61006
PDB IDs			3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6ZSI 6ZSJ
Enriched GO Terms of Interacting Partners?
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