TLL2 and HPSE2

Data Source:
BioGRID (proximity labelling technology)

		TLL2	HPSE2
Description		tolloid like 2	heparanase 2 (inactive)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Heparanase Activity Heparan Sulfate Proteoglycan Binding
	Biological Process	Proteolysis Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth	Glycosaminoglycan Catabolic Process Biological_process Positive Regulation Of Cell Population Proliferation Extracellular Matrix Organization
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	HS-GAG degradation
Drugs		Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases			Urofacial syndrome
GWAS		Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)	Asthma (childhood onset) ( 23829686) Migraine ( 27322543) Obesity-related traits ( 23251661) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482)
Interacting Genes
Entrez ID		7093	60495
HPRD ID		05993	13669
Ensembl ID		ENSG00000095587	ENSG00000172987
Uniprot IDs		Q9Y6L7	Q2M1H9 Q8WWQ2
PDB IDs
Enriched GO Terms of Interacting Partners?
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