HNF1B and ALDOC

Data Source:
BioGRID (two hybrid)

		HNF1B	ALDOC
Description		HNF1 homeobox B	aldolase, fructose-bisphosphate C
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Kidney Development Regulation Of Transcription By RNA Polymerase II Response To Carbohydrate Response To Organic Cyclic Compound Insulin Secretion Pancreas Development Circadian Regulation Of Gene Expression Regulation Of Pronephros Size Pronephric Nephron Tubule Development Response To Drug Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Pronephros Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Protein-DNA Complex Assembly Hepatocyte Differentiation	Fructose Metabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation Neutrophil Degranulation Canonical Glycolysis
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells	Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs
Diseases		Maturity onset diabetes of the young (MODY) Type II diabetes mellitus Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS		Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Endometrial cancer ( 30093612 27008869 21499250 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Epithelial ovarian cancer ( 25581431) Frontotemporal dementia ( 26154020) Gallstone disease ( 30504769) Medication use (drugs used in diabetes) ( 31015401) Neuritic plaque ( 25188341) Ovarian cancer ( 23535730) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Prostate cancer ( 20676098 18264096 18264097 30410027 31562322 25939597 26443449 27262462) Prostate-specific antigen levels ( 30410027 28139693) Serum prostate-specific antigen levels ( 21160077) Testicular germ cell tumor ( 25877299 28604728 28604732) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 22961080 32499647 20581827 30718926 28869590)
Interacting Genes		17 interacting genes: ATF1 BPIFA1 C10orf55 CREB1 CREBBP CRX H3C1 HNF1A KRTAP26-1 MLLT10 OTX2 OXER1 PCBD1 POU6F2 UFSP1 USP54 VAC14	7 interacting genes: ANKS1A ATP6V1E1 ERBB2 LNX1 MAP2K3 PLD2 SQLE
Entrez ID		6928	230
HPRD ID		08926	02386
Ensembl ID		ENSG00000275410	ENSG00000109107
Uniprot IDs		A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6	A0A024QZ64 P09972
PDB IDs		2DA6 2H8R 5K9S	1XFB
Enriched GO Terms of Interacting Partners?
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