ELOC and LY96

Data Source:
BioGRID (affinity chromatography technology)

		ELOC	LY96
Description		elongin C	lymphocyte antigen 96
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol VCB Complex Cul2-RING Ubiquitin Ligase Complex Elongin Complex	Extracellular Space Plasma Membrane Endosome Membrane Intrinsic Component Of Plasma Membrane Lipopolysaccharide Receptor Complex
	Molecular Function	Protein Binding Protein-containing Complex Binding	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity Protein Binding Coreceptor Activity Toll-like Receptor 4 Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs			Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid
Diseases
GWAS			Blood protein levels ( 29875488) Carotid plaque burden (smoking interaction) ( 24954085) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043)
Interacting Genes		35 interacting genes: ASB11 CBX5 CENPC COMMD1 CPTP CUL2 CUL3 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3P ELOB EPOR GHR ID2 JTB LRRC41 MCM7 MED8 METTL21C MRAS NOTCH4 PRAME RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 USP33 VHL WNT7B ZYG11B	8 interacting genes: CALM1 CDKN2C LCN2 MESD MLH1 SMARCB1 TLR2 TLR4
Entrez ID		6921	23643
HPRD ID		02875	05579
Ensembl ID		ENSG00000154582	ENSG00000154589
Uniprot IDs		A0A024R7Y5 Q15369	Q9Y6Y9
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6P59 6R7F 6R7H 6R7N 6SIS 6V9H 6ZHC	1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A
Enriched GO Terms of Interacting Partners?
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