TBCA and RAG1

Data Source:
BioGRID (affinity chromatography technology)

		TBCA	RAG1
Description		tubulin folding cofactor A	recombination activating 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Microtubule Microtubule Cytoskeleton	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Chaperone Binding	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response
Pathways		Post-chaperonin tubulin folding pathway	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Platelet distribution width ( 32888494)	Rheumatoid arthritis ( 24390342)
Interacting Genes		4 interacting genes: CDC42 ERBB3 TAF9 TERF2IP	17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		6902	5896
HPRD ID		18166	01556
Ensembl ID		ENSG00000171530	ENSG00000166349
Uniprot IDs		E5RIX8 O75347 Q6FGD7	P15918
PDB IDs		1H7C
Enriched GO Terms of Interacting Partners?
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