SPIB and IL2RB

Data Source:
BioGRID (affinity chromatography technology)

		SPIB	IL2RB
Description		Spi-B transcription factor	interleukin 2 receptor subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	MAPK Cascade Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways			RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Primary biliary cholangitis ( 21399635 20639880 26394269) Systolic blood pressure ( 30224653)	Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		19 interacting genes: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		6689	3560
HPRD ID		06007	00896
Ensembl ID		ENSG00000269404	ENSG00000100385
Uniprot IDs		A0A024R4I5 Q01892	P14784
PDB IDs			1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K
Enriched GO Terms of Interacting Partners?
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