SORD and KRT5

Data Source:
BioGRID (proximity labelling technology)

		SORD	KRT5
Description		sorbitol dehydrogenase	keratin 5
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GO Annotations	Cellular Component	Extracellular Space Cytosol Membrane Motile Cilium Mitochondrial Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	(R,R)-butanediol Dehydrogenase Activity L-iditol 2-dehydrogenase Activity Zinc Ion Binding Carbohydrate Binding Identical Protein Binding D-xylulose Reductase Activity Ribitol 2-dehydrogenase Activity NAD Binding	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Glucose Metabolic Process Sorbitol Catabolic Process Response To Osmotic Stress Response To Hormone Glucuronate Catabolic Process To Xylulose 5-phosphate Flagellated Sperm Motility Response To Nutrient Levels Response To Drug Fructose Biosynthetic Process Response To Cadmium Ion Response To Copper Ion L-xylitol Catabolic Process L-xylitol Metabolic Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification
Pathways		Fructose biosynthesis Formation of xylulose-5-phosphate	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs		NADH Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine	Zinc Zinc acetate
Diseases			Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476)	Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		2 interacting genes: RELA SHBG	25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A
Entrez ID		6652	3852
HPRD ID		01679	01010
Ensembl ID		ENSG00000140263	ENSG00000186081
Uniprot IDs		Q00796	P13647
PDB IDs		1PL6 1PL7 1PL8	3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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