SLC8A1 and AKAP6

Data Source:
BioGRID (affinity chromatography technology)

		SLC8A1	AKAP6
Description		solute carrier family 8 member A1	A-kinase anchoring protein 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Microtubule Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Dendritic Spine Dendritic Shaft Axon Terminus Synapse Cell Periphery Postsynapse Integral Component Of Postsynaptic Membrane	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Cation:cation Antiporter Activity Ankyrin Binding Ion Channel Binding Ion Antiporter Activity Involved In Regulation Of Postsynaptic Membrane Potential Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Protein Binding Adenylate Cyclase Binding Protein Kinase A Regulatory Subunit Binding Protein-membrane Adaptor Activity Ion Channel Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Regulation Of Sodium Ion Transport Ion Transport Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Muscle Contraction Response To Nutrient Response To Glucose Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Fibroblast Migration Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Telencephalon Development Metal Ion Transport Positive Regulation Of Bone Mineralization Response To ATP Sodium Ion Transmembrane Transport Response To Immobilization Stress Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Response To Drug Response To Hydrogen Peroxide Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To CAMP Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs		alpha-Linolenic acid Icosapent Dronedarone Caldaret
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 25055868) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30158200 30598549) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte percentage of white cells ( 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 29127183 32439900 25035420) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QT interval ( 29213071 24952745 22726844) Refractive error ( 32231278) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378) TPE interval (resting) ( 32386560)	Adult body size ( 32376654) Anorexia nervosa ( 21079607) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Creatine kinase levels ( 29403010) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (environmentalism) ( 22566634) Fasting blood insulin (BMI interaction) ( 22581228) General cognitive ability ( 29844566) Glioma ( 28346443) HDL cholesterol levels ( 32203549) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Non-glioblastoma glioma ( 28346443) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	9 interacting genes: CALM1 CDC5L DISC1 DTNBP1 PDE4D PPP2CA PRKAR2A RYR1 RYR2
Entrez ID		6546	9472
HPRD ID		01659	05257
Ensembl ID		ENSG00000183023	ENSG00000151320
Uniprot IDs		P32418 Q4QQH3	B2RP22 Q13023
PDB IDs
Enriched GO Terms of Interacting Partners?
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