NDRG4 and ADCY9

Data Source:
HPRD (in vivo)

		NDRG4	ADCY9
Description		NDRG family member 4	adenylate cyclase 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Basolateral Plasma Membrane Cell Projection Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Axon Dendrite
	Molecular Function	Molecular_function Protein Binding	Adenylate Cyclase Activity ATP Binding Metal Ion Binding
	Biological Process	Heart Looping Signal Transduction Brain Development Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling	In Utero Embryonic Development Renal Water Homeostasis CAMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Protein Kinase A Activity Cellular Response To Glucagon Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways			Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 22726844 19305408 19305409) Schizophrenia ( 29483656)	Adult body size ( 32376654) Body mass index ( 28552196 24861553 28892062 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diverticular disease ( 30177863) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference ( 25673412) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity ( 23563607) Partial epilepsies ( 20522523) Platelet count ( 32888494) Response to Dalcetrapib treatment in acute coronary syndrome ( 25583994) Systolic blood pressure ( 30578418) Thyroid stimulating hormone levels ( 30367059 32769997) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		36 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A	1 interacting genes: HSPB1
Entrez ID		65009	115
HPRD ID		14817	04489
Ensembl ID		ENSG00000103034	ENSG00000162104
Uniprot IDs		A0A024R6V8 A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0	O60503
PDB IDs
Enriched GO Terms of Interacting Partners?
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