S100P and WFS1

Data Source:
HPRD (in vivo)

		S100P	WFS1
Description		S100 calcium binding protein P	wolframin ER transmembrane glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Microvillus Membrane Secretory Granule Lumen Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein Homodimerization Activity Cadherin Binding Transition Metal Ion Binding Calcium-dependent Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding ATPase Binding
	Biological Process	Response To Organic Substance Neutrophil Degranulation Endothelial Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Neutrophil degranulation	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Cromoglicic acid
Diseases			Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Obesity-related traits ( 23251661)	Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		15 interacting genes: AGER ARC CACYBP EZR S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI UBL4A	11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1
Entrez ID		6286	7466
HPRD ID		02792	05864
Ensembl ID		ENSG00000163993	ENSG00000109501
Uniprot IDs		P25815	A0A0S2Z4V6 O76024
PDB IDs		1J55 1OZO 2MJW
Enriched GO Terms of Interacting Partners?
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