BDNF and CD44

Data Source:
BioGRID (affinity chromatography technology)

		BDNF	CD44
Description		brain derived neurotrophic factor	CD44 molecule (Indian blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Synaptic Vesicle Nuclear Speck Axon Dendrite Perinuclear Region Of Cytoplasm	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome
	Molecular Function	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Nervous System Development Axon Guidance Synapse Assembly Peripheral Nervous System Development Memory Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Receptor Binding Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis
Pathways		MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5	Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling
Drugs		CX-717 Copper Chondroitin sulfate Esketamine	Bivatuzumab Hyaluronic acid
Diseases		Congenital central hypoventilation syndrome (CCHS)	Gastric cancer
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 29381148 23563607 19079260 26961502 24861553 31453325 28892062 25673413 20935630 29273807 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption ( 31959922) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 21708048 23563607) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260) White blood cell count ( 32888494)	Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)
Interacting Genes		19 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R FAM209A GPR152 INPP5K JUNB LRP1 MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1	61 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		627	960
HPRD ID		00214	00115
Ensembl ID		ENSG00000176697	ENSG00000026508
Uniprot IDs		A0A0E3SU01 P23560	P16070
PDB IDs		1B8M 1BND	1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?
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