HPSE2 and TLL2

Data Source:
BioGRID (proximity labelling technology)

		HPSE2	TLL2
Description		heparanase 2 (inactive)	tolloid like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extracellular Matrix	Extracellular Region
	Molecular Function	Heparanase Activity Heparan Sulfate Proteoglycan Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Glycosaminoglycan Catabolic Process Biological_process Positive Regulation Of Cell Population Proliferation Extracellular Matrix Organization	Proteolysis Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		HS-GAG degradation	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs			Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases		Urofacial syndrome
GWAS		Asthma (childhood onset) ( 23829686) Migraine ( 27322543) Obesity-related traits ( 23251661) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482)	Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes
Entrez ID		60495	7093
HPRD ID		13669	05993
Ensembl ID		ENSG00000172987	ENSG00000095587
Uniprot IDs		Q2M1H9 Q8WWQ2	Q9Y6L7
PDB IDs
Enriched GO Terms of Interacting Partners?
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