RBP4 and TLL2

Data Source:
BioGRID (affinity chromatography technology)

		RBP4	TLL2
Description		retinol binding protein 4	tolloid like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Protein-containing Complex Extracellular Exosome	Extracellular Region
	Molecular Function	Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Heart Development Visual Perception Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Retinol Transport Retinol Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation	Proteolysis Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs		Tretinoin	Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases
GWAS		Blood protein levels ( 30072576) Optic disc area ( 31798171) Retinol levels ( 21878437)	Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		6 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RPE65 TTR
Entrez ID		5950	7093
HPRD ID		01580	05993
Ensembl ID		ENSG00000138207	ENSG00000095587
Uniprot IDs		P02753 Q5VY30	Q9Y6L7
PDB IDs		1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
Enriched GO Terms of Interacting Partners?
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