RASA2 and GATAD2A

Data Source:
BioGRID (affinity chromatography technology)

		RASA2	GATAD2A
Description		RAS p21 protein activator 2	GATA zinc finger domain containing 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm NuRD Complex Nuclear Speck
	Molecular Function	GTPase Activator Activity Phospholipid Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding
	Biological Process	MAPK Cascade Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		Regulation of RAS by GAPs	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Basophil count ( 32888494) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062 25673413 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Prion diseases ( 22210626) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Refractive error ( 32231278) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Weight ( 28552196) White blood cell count ( 32888494 27863252)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		2 interacting genes: GNA12 HRAS	15 interacting genes: CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 SPOP
Entrez ID		5922	54815
HPRD ID		03351	11741
Ensembl ID		ENSG00000155903	ENSG00000167491
Uniprot IDs		Q15283	A0A024R7K7 A0A024R7M6 Q86YP4
PDB IDs			2L2L
Enriched GO Terms of Interacting Partners?
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