RAG1 and TBCA

Data Source:
BioGRID (affinity chromatography technology)

		RAG1	TBCA
Description		recombination activating 1	tubulin folding cofactor A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Nucleolus Cytoplasm Cytosol Microtubule Microtubule Cytoskeleton
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Chaperone Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Post-chaperonin tubulin folding pathway
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H	4 interacting genes: CDC42 ERBB3 TAF9 TERF2IP
Entrez ID		5896	6902
HPRD ID		01556	18166
Ensembl ID		ENSG00000166349	ENSG00000171530
Uniprot IDs		P15918	E5RIX8 O75347 Q6FGD7
PDB IDs			1H7C
Enriched GO Terms of Interacting Partners?
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