RAG1 and CAPRIN1

Data Source:
BioGRID (affinity chromatography technology)

		RAG1	CAPRIN1
Description		recombination activating 1	cell cycle associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Synapse
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity	RNA Binding Protein Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response	Negative Regulation Of Translation Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Iron status biomarkers (transferrin saturation) ( 28334935) Systolic blood pressure ( 30224653)
Interacting Genes		17 interacting genes: APP DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 RAG2 UBC UBE2C UBE2D1 UBE2D2 UBE2H	6 interacting genes: APP DAPK1 MFHAS1 PIN1 PRMT1 WBP4
Entrez ID		5896	4076
HPRD ID		01556	03108
Ensembl ID		ENSG00000166349	ENSG00000135387
Uniprot IDs		P15918	Q14444
PDB IDs			4WBE 4WBP
Enriched GO Terms of Interacting Partners?
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