PTBP2 and GBP1

Data Source:
BioGRID (affinity chromatography technology)

		PTBP2	GBP1
Description		polypyrimidine tract binding protein 2	guanylate binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Cytoplasmic Vesicle
	Molecular Function	RNA Binding MRNA Binding	Actin Binding GTPase Activity Protein Binding GTP Binding GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	MRNA Splice Site Selection Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Interleukin-2 Production Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)	Remission after SSRI treatment in MDD or openness ( 29559929)
Interacting Genes		19 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1	2 interacting genes: FNTA FNTB
Entrez ID		58155	2633
HPRD ID		12233	02681
Ensembl ID		ENSG00000117569	ENSG00000117228
Uniprot IDs		A0A6Q8PFE6 B4DSS8 B4DSU5 Q9UKA9	P32455
PDB IDs		2CQ1 2MJU 4CQ1	1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D
Enriched GO Terms of Interacting Partners?
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