ZNF608 and LOX

Data Source:
BioGRID (proximity labelling technology)

		ZNF608	LOX
Description		zinc finger protein 608	lysyl oxidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Collagen Trimer Extracellular Space Nucleus Extracellular Matrix
	Molecular Function	Metal Ion Binding	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Osteoblast Differentiation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Heart Development Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Protein Phosphopantetheinylation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Ascending Aorta Development Descending Aorta Development Wound Healing Response To Drug Regulation Of Apoptotic Process Protein Kinase B Signaling Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Muscle Fiber Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Receptor Binding Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Asthma (childhood onset) ( 27611488) B6 vitamer levels (multivariate analysis) ( 30583557) Body mass index ( 23669352 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol levels ( 32203549) IgM levels ( 28628107) Metabolite levels ( 23823483) Monobrow ( 27182965) Nicotine dependence ( 28440896) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 32439900) Refractive error ( 32231278) Subcutaneous adipose tissue ( 22589738) Survival in pancreatic cancer ( 28470677) Type 2 diabetes (young onset) and obesity ( 24465431) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Central corneal thickness ( 32528159) Coronary artery disease ( 28714974) Intraocular pressure ( 29617998) Lung function (FEV1/FVC) ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Youthful appearance (self-reported) ( 32339537)
Interacting Genes			8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 RAF1
Entrez ID		57507	4015
HPRD ID		18357	01087
Ensembl ID		ENSG00000168916	ENSG00000113083
Uniprot IDs		B3KPE6 Q9ULD9	B0AZT2 B7ZAJ4 D0PNI2 P28300
PDB IDs
Enriched GO Terms of Interacting Partners?
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