ARID1B and MTHFD1L

Data Source:
BioGRID (affinity chromatography technology)

		ARID1B	MTHFD1L
Description		AT-rich interaction domain 1B	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane SWI/SNF Complex Brahma Complex NBAF Complex	Mitochondrion Mitochondrial Matrix Cytosol Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nucleosome Binding	Formate-tetrahydrofolate Ligase Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity ATP Binding Protein Homodimerization Activity
	Biological Process	Response To Ischemia Regulation Of Transcription By RNA Polymerase II Nervous System Development ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Chromatin-mediated Maintenance Of Transcription Cellular Response To Angiotensin	Neural Tube Closure Folic Acid-containing Compound Metabolic Process 10-formyltetrahydrofolate Biosynthetic Process Formate Metabolic Process Tetrahydrofolate Interconversion Folic Acid Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Metabolism of folate and pterines
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease biomarkers ( 23419831) Calcium levels ( 24068962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Iris color (b* coordinate) ( 30895295) Lipoprotein (a) levels ( 26377243) Low density lipoprotein cholesterol levels ( 30498476) Multiple system atrophy (pathologically confirmed) ( 27629089) Pancreatic cancer ( 22158540) Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale) ( 28525603) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Type 2 diabetes ( 29621232) Vein graft stenosis in coronary artery bypass grafting ( 25881214) Western dietary pattern ( 28644415)	Alzheimer's disease (late onset) ( 20885792) Chronic myeloid leukemia ( 21540461) Coronary heart disease ( 17634449) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Type 2 diabetes ( 25760438)
Interacting Genes		7 interacting genes: CUL2 ENO1 H2BC21 PYGM SMAD9 SMARCA2 SMARCA4	1 interacting genes: HGS
Entrez ID		57492	25902
HPRD ID		10660	09967
Ensembl ID		ENSG00000049618	ENSG00000120254
Uniprot IDs		Q8NFD5	A0A087WVM4 B2RD24 B7ZM99 Q6UB35
PDB IDs		2CXY 2EH9
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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