SPIRE1 and CEP192

Data Source:
BioGRID (two hybrid)

		SPIRE1	CEP192
Description		spire type actin nucleation factor 1	centrosomal protein 192
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton Cell Cortex Cytoplasmic Vesicle Membrane Integral Component Of Mitochondrial Outer Membrane Cleavage Furrow Perinuclear Region Of Cytoplasm	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol
	Molecular Function	Actin Binding Protein Binding	Protein Binding Protein Kinase Binding Phosphatase Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Actin Cytoskeleton Organization Actin Filament Polymerization Cleavage Furrow Formation Polar Body Extrusion After Meiotic Divisions Actin Nucleation Intracellular Transport Golgi Vesicle Transport Establishment Of Meiotic Spindle Localization Actin Filament Network Formation Formin-nucleated Actin Cable Assembly Positive Regulation Of Mitochondrial Fission Positive Regulation Of Double-strand Break Repair	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Response To Bacterium Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphatase Activity Centrosome Duplication Protein Localization To Centrosome Centrosome-templated Microtubule Nucleation Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Red blood cell count ( 32888494)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566)
Interacting Genes		1 interacting genes: BBS4	3 interacting genes: LINC00839 SHBG UBC
Entrez ID		56907	55125
HPRD ID		11600	10855
Ensembl ID		ENSG00000134278	ENSG00000101639
Uniprot IDs		Q08AE8	Q8TEP8 Q9HCK3
PDB IDs		2YLE 2YLF 3R7G 3RBW	4N7Z 6FVI 6W3J
Enriched GO Terms of Interacting Partners?
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