CYP26B1 and PCYOX1

Data Source:
BioGRID (affinity chromatography technology)

		CYP26B1	PCYOX1
Description		cytochrome P450 family 26 subfamily B member 1	prenylcysteine oxidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane	Lysosome Plasma Membrane Very-low-density Lipoprotein Particle Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding	Prenylcysteine Oxidase Activity Protein Binding ATPase-coupled Chloride Transmembrane Transporter Activity
	Biological Process	Cell Fate Determination Establishment Of T Cell Polarity Kidney Development Vitamin Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Male Meiotic Nuclear Division Spermatogenesis Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Sterol Metabolic Process Embryonic Limb Morphogenesis Response To Vitamin A Retinoic Acid Catabolic Process Retinoic Acid Metabolic Process Tongue Morphogenesis Regulation Of T Cell Differentiation Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation	Prenylated Protein Catabolic Process Prenylcysteine Catabolic Process Chloride Transmembrane Transport
Pathways		Vitamins RA biosynthesis pathway Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Drugs		Tretinoin
Diseases
GWAS		Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Heel bone mineral density ( 30598549) Height ( 31562340) IgA levels ( 28628107) Malaria ( 31844061) Schizophrenia ( 25056061)	Acne (severe) ( 24927181) Chronotype ( 30696823) Male-pattern baldness ( 28196072) Morning person ( 30696823)
Interacting Genes		1 interacting genes: NEDD4L	1 interacting genes: HOXA1
Entrez ID		56603	51449
HPRD ID		05550	11422
Ensembl ID		ENSG00000003137	ENSG00000116005
Uniprot IDs		E7ER08 Q9NR63	Q9UHG3
PDB IDs
Enriched GO Terms of Interacting Partners?
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