RELN and PCOLCE

Data Source:
BioGRID (affinity chromatography technology)

		RELN	PCOLCE
Description		reelin	procollagen C-endopeptidase enhancer
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Dendrite Neuron Projection	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Hippocampus Development Cerebral Cortex Tangential Migration Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation Positive Regulation Of Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Multicellular Organism Development Positive Regulation Of Peptidase Activity
Pathways		Reelin signalling pathway	Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) SjÃ¶gren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Resting heart rate ( 27798624) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR	5 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG
Entrez ID		5649	5118
HPRD ID		02742	02603
Ensembl ID		ENSG00000189056	ENSG00000106333
Uniprot IDs		P78509	Q15113
PDB IDs			1UAP 6FZV 6FZW
Enriched GO Terms of Interacting Partners?
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