GSDMB and DHRS11

Data Source:
BioGRID (affinity chromatography technology)

		GSDMB	DHRS11
Description		gasdermin B	dehydrogenase/reductase 11
Image
GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane	Cellular_component Extracellular Region
	Molecular Function	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding 3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity 17-beta-ketosteroid Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Cytolysis Defense Response To Bacterium Pyroptosis	Steroid Biosynthetic Process Estrogen Biosynthetic Process
Pathways
Drugs			Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)	Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	1 interacting genes: DLG3
Entrez ID		55876	79154
HPRD ID		17082	08331
Ensembl ID		ENSG00000073605	ENSG00000278535
Uniprot IDs		Q8TAX9	A0A024R0T1 Q6UWP2
PDB IDs		5TIB 5TJ2 5TJ4	1XG5
Enriched GO Terms of Interacting Partners?
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