PRKD1 and DGKH

Data Source:
BioGRID (affinity chromatography technology)

		PRKD1	DGKH
Description		protein kinase D1	diacylglycerol kinase eta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane	Cytoplasm Endosome Plasma Membrane Actin Cytoskeleton Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Metal Ion Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Cell Differentiation Regulation Of Protein Stability Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Cellular Response To Hydroperoxide Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Phosphatidic Acid Biosynthetic Process Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Lipid Phosphorylation
Pathways		Sphingolipid de novo biosynthesis	Effects of PIP2 hydrolysis
Drugs		Bryostatin 1 Fostamatinib	alpha-Tocopherol succinate
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28552196 23669352 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656 30285260) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)	Bipolar disorder ( 17486107) Blood urea nitrogen levels ( 29403010) Body size at age 10 ( 32376654) Calcium levels ( 24068962) Cortisol levels (saliva) ( 28843169) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Height ( 20189936) Kidney stones ( 31729369) Metabolite levels (X-11787) ( 23934736) Nephrolithiasis ( 22396660) Plasma anti-thyroglobulin levels ( 29678681) Pulmonary function in asthmatics ( 25221879) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		34 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ YWHAZ	2 interacting genes: DGKD TRAF5
Entrez ID		5587	160851
HPRD ID		05668	07237
Ensembl ID		ENSG00000184304	ENSG00000102780
Uniprot IDs		F8WBA3 Q15139	A8K0I1 B4DYW1 Q86XP1
PDB IDs
Enriched GO Terms of Interacting Partners?
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