TMEM126B and ALG8

Data Source:
BioGRID (biochemical)

		TMEM126B	ALG8
Description		transmembrane protein 126B	ALG8 alpha-1,3-glucosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding	Alpha-1,3-mannosyltransferase Activity Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Mannosylation
Pathways		Complex I biogenesis	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes ALG8-CDG (CDG-1h)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Height ( 19570815) Metabolite levels ( 23823483)	Depression in smokers ( 30219690) Tourette syndrome ( 30818990)
Interacting Genes		2 interacting genes: APP MRFAP1L1	12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A
Entrez ID		55863	79053
HPRD ID		13715	10480
Ensembl ID		ENSG00000171204	ENSG00000159063
Uniprot IDs		A0A024R5L4 Q8IUX1	A0A024R5K5 Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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