PRKCH and SIX6

Data Source:
BioGRID (biochemical)

		PRKCH	SIX6
Description		protein kinase C eta	SIX homeobox 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis
Pathways		Effects of PIP2 hydrolysis G alpha (z) signalling events
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Asthma ( 32296059) Height ( 28552196) Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 30423114 22446963 24390342) Word reading ( 23738518) Yeast infection ( 28928442)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 29891935 25173105 29452408 22570617) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 25631615 31798171 28073927) Refractive error ( 23396134 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 31798171 25241763 28073927)
Interacting Genes		12 interacting genes: BANP CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS	3 interacting genes: GTF2A1L TLE1 TLE5
Entrez ID		5583	4990
HPRD ID		05669	07557
Ensembl ID		ENSG00000027075	ENSG00000184302
Uniprot IDs		P24723	O95475 Q6P051
PDB IDs		2FK9 3TXO
Enriched GO Terms of Interacting Partners?
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