AMBRA1 and PEX11A

Data Source:
BioGRID (affinity chromatography technology)

		AMBRA1	PEX11A
Description		autophagy and beclin 1 regulator 1	peroxisomal biogenesis factor 11 alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Neural Tube Development Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Peroxisome Organization Signal Transduction Peroxisome Membrane Biogenesis Peroxisome Fission Regulation Of Lipid Metabolic Process Regulation Of Peroxisome Size Brown Fat Cell Differentiation
Pathways		Macroautophagy	PPARA activates gene expression
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Height ( 31562340)
Interacting Genes		12 interacting genes: BECN1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBE2D3	1 interacting genes: PEX19
Entrez ID		55626	8800
HPRD ID		10975	04843
Ensembl ID		ENSG00000110497	ENSG00000166821
Uniprot IDs		A0A075B6T1 Q9C0C7	B2R8C6 B4DMF6 O75192
PDB IDs
Enriched GO Terms of Interacting Partners?
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